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Laboratory Markers in the Diagnosis of Thrombosis-GoLab on World Thrombosis Day

Author: Site Editor     Publish Time: 2023-10-13      Origin: Site


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World Thrombosis Day: Stop Blood Clots and Save Lives

World Thrombosis Day, observed on October 13 every year, aims to raise awareness of the risk factors, symptoms, and prevention of thrombosis. It also encourages people to seek medical attention if they suspect they have a blood clot. World Thrombosis Day serves as a poignant reminder of the significance of understanding and addressing thrombosis, a condition where blood clots form in the veins or arteries. Thrombosis can lead to potentially fatal complications like deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke. Therefore, early diagnosis and intervention are crucial.

Diagnostic Assays: Tools for Early Detection

Three major diagnostic assays play a pivotal role in the early detection and monitoring of thrombosis-related conditions: D-Dimer, cTnI (cardiac Troponin I), and NTproBNP (N-terminal prohormone of brain natriuretic peptide).


What is it? A small protein fragment present in the blood after a blood clot dissolves.

Why is it used? Elevated D-Dimer levels can indicate the presence of an abnormal clotting process, making it a valuable tool for diagnosing DVT or PE. However, it's worth noting that D-Dimer can be elevated in other conditions too, so it's essential to interpret results within the clinical context.

cTnI (cardiac Troponin I):

  • What is it? A protein found in heart muscle cells that controls the contraction of the heart. When there's damage to the heart, cTnI is released into the bloodstream.

  • Why is it used? Elevated cTnI levels can indicate a heart attack or other forms of heart injury. In the context of thrombosis, a heart attack can be caused by a blood clot blocking a coronary artery.

NTproBNP (N-terminal prohormone of brain natriuretic peptide):

  • What is it? A marker of heart failure, it's released into the bloodstream in response to changes in pressure inside the heart.

  • Why is it used? Elevated NTproBNP levels can indicate heart failure. A clot in the lungs (PE) can strain the right side of the heart, potentially leading to heart failure. Thus, measuring NTproBNP can help diagnose and monitor this strain.

Why are Diagnostic Assays Important?

  • Early Detection: These assays can detect the presence of thrombosis-related conditions even before overt symptoms appear.

  • Treatment Decisions: Assay results guide clinicians in making informed decisions regarding the need for further tests, treatment initiation, or modification.

  • Risk Stratification: They help determine the severity of the disease, allowing for risk stratification and better management of patients.

On this World Thrombosis Day, let's raise awareness of the vital role these diagnostic assays play in saving lives. 

Understanding thrombosis and its potential risks is the first step in prevention and ensuring better outcomes for those affected.

Stay informed. Stay safe.

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