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1. Intended Use
This product is used on GPP-100 Specific Protein Analyzer for quantitative determination of Immunoglobulin A (IgA) in human blood (or serum or plasma) as an aid in the diagnosis of abnormal IgA metabolism.
2. Summary
IgA accounts for 13% of the serum immunoglobulins and plays important roles in mucosa immunity. It is capable of binding to toxins and viruses, thereby protecting the skin and mucosa against microorganisms. IgA is the predominant immunoglobulin in body secretions such as colostrum, saliva and sweat. Secretory IgA provides defense against local infections and is important in protecting the gastrointestinal tract from the antigens in food.
Increased polyclonal IgA levels may occur in chronic liver diseases, chronic infections, autoimmune disorders (e.g. rheumatoid arthritis, Systemic Lupus Erythematosus), sarcoidosis and Wiskott-Aldrich syndrome. Monoclonal IgA increases in IgA multiple myeloma. Decreased synthesis of IgA is observed in congenital and acquired immunodeficiency diseases such as Bruton type agammaglobulinemia. Protein-losing gastroenteropathy and burns may also lead to reduced IgA levels.
1. Intended Use
This product is used on GPP-100 Specific Protein Analyzer for quantitative determination of Immunoglobulin A (IgA) in human blood (or serum or plasma) as an aid in the diagnosis of abnormal IgA metabolism.
2. Summary
IgA accounts for 13% of the serum immunoglobulins and plays important roles in mucosa immunity. It is capable of binding to toxins and viruses, thereby protecting the skin and mucosa against microorganisms. IgA is the predominant immunoglobulin in body secretions such as colostrum, saliva and sweat. Secretory IgA provides defense against local infections and is important in protecting the gastrointestinal tract from the antigens in food.
Increased polyclonal IgA levels may occur in chronic liver diseases, chronic infections, autoimmune disorders (e.g. rheumatoid arthritis, Systemic Lupus Erythematosus), sarcoidosis and Wiskott-Aldrich syndrome. Monoclonal IgA increases in IgA multiple myeloma. Decreased synthesis of IgA is observed in congenital and acquired immunodeficiency diseases such as Bruton type agammaglobulinemia. Protein-losing gastroenteropathy and burns may also lead to reduced IgA levels.
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