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This product is used on GPP-100 Specific Protein Analyzer for quantitative determination of Immunoglobulin M (IgM) in human serum or plasma as an aid in diagnosis of abnormal IgM metabolism.
IgM is the largest immunoglobulin molecule (MW = 970,000 Da) and makes up 6% of the plasma immunoglobulins. IgM is the first specific antibody to appear in the serum after infection. It is capable of activating complement, thus helping to kill bacteria. After the infection has subsided, IgM levels sink at a relatively rapid rate compared to IgG. This fact is used in the differential diagnosis of acute and chronic infections by comparing specific IgM and IgG titers. If IgM is prevalent the infection is acute, whereas if IgG predominates the infection is chronic.
Increased polyclonal IgM levels are found in viral, bacterial, and parasitic infections, liver diseases, rheumatoid arthritis, scleroderma, cystic fibrosis. Monoclonal IgM is increased in Waldenström's macroglobulinemia. Increased loss of IgM is found in protein-losing enteropathies and in burns. Decreased synthesis of IgM occurs in congenital and acquired immunodeficiency syndromes. The IgM concentration in serum from infants is lower than in that from adults.
This product is used on GPP-100 Specific Protein Analyzer for quantitative determination of Immunoglobulin M (IgM) in human serum or plasma as an aid in diagnosis of abnormal IgM metabolism.
IgM is the largest immunoglobulin molecule (MW = 970,000 Da) and makes up 6% of the plasma immunoglobulins. IgM is the first specific antibody to appear in the serum after infection. It is capable of activating complement, thus helping to kill bacteria. After the infection has subsided, IgM levels sink at a relatively rapid rate compared to IgG. This fact is used in the differential diagnosis of acute and chronic infections by comparing specific IgM and IgG titers. If IgM is prevalent the infection is acute, whereas if IgG predominates the infection is chronic.
Increased polyclonal IgM levels are found in viral, bacterial, and parasitic infections, liver diseases, rheumatoid arthritis, scleroderma, cystic fibrosis. Monoclonal IgM is increased in Waldenström's macroglobulinemia. Increased loss of IgM is found in protein-losing enteropathies and in burns. Decreased synthesis of IgM occurs in congenital and acquired immunodeficiency syndromes. The IgM concentration in serum from infants is lower than in that from adults.
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