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Diagnostics for SLE: The Autoimmune Disease Made The Headline

Author: Site Editor     Publish Time: 2023-12-15      Origin: Site


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Health Watch


Hongkong born actress Kathy Chow, suddenly died at her 57 in Beijing on December 11. She was known by many for her role in TV series The Heaven Sword And Dragon Sabre (1994), an adaptation of late writer Louis Cha’s martial arts novel.
Reports had previously surfaced suggesting that she was battling the autoimmune disease lupus, which had reportedly impacted her professional endeavors.
Soon after the announcement, a photo of Chow’s medical records began circulating online.According to the leaked document, the patient, who lived alone, suffered from high blood pressure and systemic lupus erythematosus(SLE).

Her shocking death news soon arise discussions online on the the disease SLE.

What is SLE?

Systemic Lupus Erythematosus (SLE) is a heterogeneous incurable autoimmune disorder characterized by both B- and T-cell dysfunction that results in immune-mediated multi-system tissue damage.

What is the diagnostics criteria for SLE

The standard testing criteria for SLE is positice ANA. In 2019, the 2019 EULAR/ACR classification criteria for SLE include positive ANA at least once as obligatory entry criterion; followed by additive weighted criteria grouped in 7 clinical (constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, renal) and 3 immunologic (antiphospholipid antibodies, complement proteins, SLE- specific antibodies) domains, and weighted from 2 to 10. Patients accumulating ≥10 points are classified.The potential implications of having very high scores on disease severity and subsequent prognosis. This multiphase methodologic approach and classification system using a hierarchically clustered criteria established a paradigm shift in the classification of SLE.


Compliment 3 and Compliment 4 in SLE

While standard laboratory testing for SLE includes antinuclear antibody (ANA) and anti-double-stranded DNA (anti-dsDNA) among other autoantibodies, complement activation has proven pivotal in the pathogenesis of SLE-related immune complex damage.

Complement activation plays a key role in the pathophysiology of SLE and it is recommended to continue monitoring serum levels of C3 and C4 to assess for disease activity.


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Goldsite offers autoimmune disease panel test including C3 & C4 on our Specific Protein total solutions


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[1] HK actress Kathy Chow Hoi-mei dies at age 57. (2023, December 13). Retrieved December 15, 2023, from chinadailyhk website: https://www.chinadailyhk.com/article/366381#HK-actress-Kathy-Chow-Hoi-mei-dies-at-age-57
[2] Lim, R. Y. (2023, December 14). Death of actress Kathy Chow: Beijing police detain man who leaked her medical records. The Straits Times. Retrieved from https://www.straitstimes.com/life/entertainment/death-of-actress-kathy-chow-beijing-police-detain-man-who-leaked-her-medical-records
[3] Aringer, M., Costenbader, K., Daikh, D., Brinks, R., Mosca, M., Ramsey‐Goldman, R., … Lerstrøm, K. (2019). 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis & Rheumatology, 71(9), 1400–1412. https://doi.org/10.1002/art.40930
[4] Sandhu, V., & Quan, M. (2017). SLE and Serum Complement: Causative, Concomitant or Coincidental? The Open Rheumatology Journal, 11(doi: 10.2174/1874312901711010113), 113–122. https://doi.org/10.2174/1874312901711010113
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